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5-25-21

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Ear tubes or antibiotics best for repeat infections in children?

  • A study found that placing tympanostomy tubes in young children did not reduce the overall number of ear infections any more than oral antibiotic treatment.
  • The findings may help to inform guidelines for treating children with recurrent ear infections.

Ear infections are among the most common illnesses in U.S. children. They occur when bacteria or viruses infect the area behind the ear drum called the middle ear. Parts of the middle ear become swollen or blocked, trapping fluid behind the ear drum. This leads to pressure and pain, and can also affect hearing.

Childhood ear infections are often treated with oral antibiotics. But using antibiotics too often can cause bacteria to become resistant, so doctors may wait to see if mild ear infections clear up on their own. Some children experience frequent ear infections. For them, doctors may recommend surgery to place a tiny tube in the ear drum, called a tympanostomy tube, to provide ventilation to the middle ear. This helps to drain fluid and prevent future buildup.

Studies comparing ear tubes to oral antibiotic treatment for recurring childhood ear infections have had mixed results. Most were conducted before the pneumococcal vaccine became standard for young children. This protects against strains of bacteria that commonly cause ear infections.

A research team led by Drs. Alejandro Hoberman at the University of Pittsburgh and Diego Preciado of Children's National Medical Center looked at whether tubes reduced the rate of ear infection compared with treating each infection with an oral antibiotic. The study was funded by NIH's National Institute on Deafness and Other Communication Disorders (NIDCD) and National Center for Advancing Translational Sciences (NCATS). It appeared in the New England Journal of Medicine on May 13.

Researchers randomly assigned 250 ear infection-prone children, 6 to 35 months of age, to receive either ear tubes and antibiotic ear drops or medical management with oral antibiotics. All children had a history of at least 3 ear infections within 6 months or at least 4 within 12 months prior to entering the study. They had also received the pneumococcal vaccine. The children were then followed for 2 years.

The team found no difference in the study's main measure, the total number of ear infections, between the groups. Though the children in the medical management group received more oral antibiotics, the researchers did not find evidence of increased bacterial resistance in their nose and throat samples. There were also no differences in the percentage of severe infections or impact on the children's quality of life.

Of the 121 children being managed with oral antibiotics, 54 underwent tube placement during the study-35 because of failure of medical management and 19 at the request of the parent. Of the 129 children assigned to receive ear tubes, the parents of 13 declined surgery. Because of these changes, the team conducted a secondary analysis limited to children who remained in their original treatment groups. This analysis found a small benefit to the surgical approach: there were an average of 1.47 ear infections per child in the surgical group compared to 1.72 among those receiving oral antibiotics.

Although the two approaches led to a similar number of ear infections, the team did find some advantages to ear tube placement. Children in this group had their first ear infection an average of two months later than those receiving oral antibiotics. They also had fewer days with symptoms related to their ear infection, other than drainage from the ear.

"We used to often recommend tubes to reduce the rate of ear infections, but in our study, episodic antibiotic treatment worked just as well for most children," Hoberman explains.

Another theoretical reason to resort to tubes is to prevent the development of bacterial resistance, Hoberman adds, "but in this trial, we did not find increased resistance with oral antibiotic use."

-by Erin Bryant

For further information on this and other health topics, visit the web site of the National Institute of Health at www.nih.gov.

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